Projects
Over the last 2 decades CIIMS Diagnostics and Services have undertaken number of projects, funded as well as non-funded.
Our sanctioned and funded projects include both national as well as international projects.
- Development of a kit for detection of Mycobacterium tuberculosis antigen in cerebrospinal fluid of tuberculosis meningitis patients
- Diagnostic value of 30 KD proteins comprising of Ag 85 complex in extra CNS tuberculosis.
- A novel multiplex PCR for simultaneous identification and discrimination of M. tuberculosis complex, M. avium complex and other non- tubercular mycobacteria (NTM) directly from clinical specimens
- Proteomic approach for differential diagnosis of latent TB from active tuberculosis
- Development of immunological test for early diagnosis of Chikungunya (CHIKV) viral infection
- Study of Heat Shock proteins and cytokines in Diagnosis and pathogenesis of Tuberculous Meningitis
- Development of low cost prognostic kit (S) for brain stroke
- Novel method of in-vitro production of polyclonal antibodies: An alternative to animal experiments
- Study of incidence, dynamics of transmission and novel biomarkers for Zoonotic diseases from Central India.
- Possible Implications of Bioavailable Iron in Coal Mine Dust On Coal Workers’ Lung Disease.
- Screening of human Brucellosis infection in North east regions (Shillong) using point of care immunological and molecular tools
- Role of Gut microbiome in chronic inflammatory diseases: developing tools for analysis of interventions.
- Difficile in urbanized and tribal communities in Central India: A molecular Epidemiology Study
- Multiplex PCR for Determining Aetiology of Infectious Diarrhoea in Rural, Peri-urban and Urban Populations in Central India: A Case-Control Study in Partnership with CIIMs Laboratory and MAHAN Trust
- Establishment of regional Network of Clinical Laboratories in for diagnosing and Managing Clostridioides difficile infection.
- Local Evaluation of RT-PCR vs. NGS for detection, surveillance and prevention of communicable viral disease in Central India: A waste water based epidemiology study.
- Studies of various biomarkers in diagnosis and pathogenesis of Pulmonary Tuberculosis and Extra pulmonary Tuberculosis have been undertaken using various technique such as ELISA, Proteomics, PCR and Animal Cell Culture & BAcT/ALERT 3D
- Analysis of fatty acid profiles of Mycobacterium tuberculosisisolated from various clinical specimens by using Gas Chromatography – Fatty Acid Methyl Esterase (GC-FAMEs).
- Prime boost strategies using novel antigens and peptides of MTB to improve efficacy of BCG vaccine in cell line and animal models.
- Invitro Antibody production using Goat Peripheral Blood Mononuclear Cell Model (PBMC)
- Differential Diagnosis of Latent from Active Tuberculosis using Immunological and Proteomic Biomarkers
- Study of biomarkers for diagnosis and prognosis of Acute Ischemic Stroke is being carried out.
- Development of animal model to study biomarkers in post stroke brain edema.
- Standardization and evaluation of Pseudomonas and Streptococcus nested PCR for detection of bacterial meningitis has been undertaken.
- Diagnosis of Chikungunya by ELISA based methods
- Studies have been undertaken for diagnosis of Chikungunya infection by detecting viral antigen in blood and CSF samples.
- Development of in house diagnostic kit of neuroviruses has been undertaken.
- A new experimental protocol is being developed to analyze HSV (Herpes Simplex Virus) viral load in blood and CSF samples.
- Identification and Characterization of Ayurvedic Drugs useful in clot lysis and immunomodulation has being carried out.
- Development of endothelial cell line model to investigate the clot lytic activity of Ayurvedic drugs.
- Neuroprotective effects of some Ayurvedic drugs in treatment of Ischemic stroke in animal model.
National Sanctioned Ongoing Projects | ||||||
Sr. No | Title | Funding Agency/Scheme | Cost (In lakh) | Status | Duration | |
2 | Evaluation of Cow urine distillate as a bio-enhancer to increase the efficacy of anti-TB drugs against M.tuberculosis infection | Ayush Scheme, Ministry of Ayush, Govt. of India | 69.84 | Ongoing | 2021-2024 | |
1 | Screening of human Brucellosis infection in North east regions (Shillong) using point of care immunological and molecular tools | DBT-Tweaning | 24.22 | Ongoing | May 2018-2021 | |
| Sanctioned Completed Project CIIMS (2006 onwards) | ||||
| Sr. No | Title | Funding Agency/Scheme | Duration | Cost (In lakh) |
| 10 | POSSIBLE IMPLICATIONS OF BIOAVAILABLE IRON IN COAL MINE DUST ON COAL WORKERS’ LUNG DISEASE. | CMPDI (Collaborative) | 2016-2018 | 18.93 |
| 9 | Study of incidence, dynamics of transmission and novel biomarkers for Zoonotic diseases from Central India. | ICMR | 2014-2017 | 137.691 |
| 8 | Novel method of in-vitro production of polyclonal antibodies: An alternative to animal experiments | Council of Scientific and Industrial Research (CSIR) ,Govt. of India | 2013-2016 | 49.9 |
| 7 | Development of low cost prognostic kit (S) for brain stroke | Department of Biotechnology (DBT), Govt. of India | 2011-2014 | 18.53 |
| 6 | Study of Heat Shock proteins and cytokines in Diagnosis and pathogenesis of Tuberculous Meningitis | ICMR | 2009-2013 | 22.8 |
| 5 | Development of immunological test for early diagnosis of Chikungunya (CHIKV) viral infection | Department of Biotechnology (DBT), Govt. of India | 2008-11 | 24.06 |
| 4 | Proteomic approach for differential diagnosis of latent TB from active tuberculosis | Department of Biotechnology (DBT), Govt. of India | 2008-11 | 19.86 |
| 3 | A novel multiplex PCR for simultaneous identification and discrimination of M.tuberculosis complex, M.avium complex and other non- tubercular mycobacteria (NTM) directly from clinical specimens | Department of Biotechnology (DBT), Govt. of India | 2007-10 | 11 |
| 2 | Diagnostic value of 30 KD proteins comprising of Ag 85 complex in extra CNS tuberculosis. | Department of Science and Technology (DST) , Govt. of India | 2006-09 | 7.92 |
| 1 | Development of a kit for detection of Mycobacterium tuberculosis antigen in cerebrospinal fluid of tuberculosis meningitis patients | Department of Biotechnology (DBT), Govt. of India | 2006-09 | 2.77 |
International Sanctioned Ongoing Projects | ||||||
Sr. No | Title | Funding Agency/Scheme | Cost (In lakh) | Status | Duration | |
1 | Local Evaluation of RT-PCR vs. NGS for detection, surveillance and prevention of communicable viral disease in Central India: A waste water based epidemiology study. | GCRF University of Nothingham | 222.2 | Ongoing | Feb 21 – July 21 | |
International Sanctioned Completed Projects | |||||
Sr. No | Title | Funding Agency/Scheme | Duration | Cost (In lakh) | |
4 | Establishment of regional Network Of Clinical Laboratories in for diagnosing and Managing Clostridioides difficile infection. | Interdisciplinary Research Clusters Flexible Funding | Feb 2020 to July 2020 | 13.34 | |
3 | Multiplex PCR for Determining Aetiology of Infectious Diarrhoea in Rural, Peri-urban and Urban Populations in Central India: A Case-Control Study in Partnership with CIIMs Laboratory and MAHAN Trust | Research Priority Area Development Funding (RPA) | Aug-18 | 14.42 | |
2 | C. Difficile in urbanized and tribal communities in Central India: A molecular Epidemiology Study | University of Nothingham | 2019-2020 | 52.07 | |
1 | Role of Gut microbiome in chronic inflammatory diseases: developing tools for analysis of interventions. | University of Nothingham | 2018 | 4 | |